Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.
|
26545630 |
2016 |
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold.
|
22015309 |
2012 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
|
19267250 |
2009 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal.
|
17003362 |
2006 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression.
|
29848725 |
2018 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
|
19267250 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
An association of the rs1800795 SNP of the IL-6 gene with T2D has been detected for the first time in Cretans.
|
29957071 |
2018 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression.
|
29848725 |
2018 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men.
|
28296724 |
2017 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study examined a possible association of the G>C polymorphism at nucleotide -174 in the promoter region of the interleukin-6 (IL-6) gene (rs1800795) with the prevalence of diabetic complications in 235 patients with type 1 and 498 patients with type 2 diabetes.
|
19140096 |
2009 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men.
|
28296724 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus.
|
22075267 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes.
|
25222779 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results.
|
18752089 |
2009 |
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer.
|
26535651 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.070 |
GeneticVariation
|
BEFREE |
IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein.
|
28651253 |
2017 |
Ischemic stroke
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke.
|
20622166 |
2010 |